Defining the antibody cross-reactome against the influenza virus surface glycoproteins
Identifieur interne : 000335 ( Main/Exploration ); précédent : 000334; suivant : 000336Defining the antibody cross-reactome against the influenza virus surface glycoproteins
Auteurs : Raffael Nachbagauer [États-Unis] ; Angela Choi [États-Unis] ; Ariana Hirsh [États-Unis] ; Irina Margine [États-Unis] ; Sayaka Iida [Japon] ; Aldo Barrera [Chili] ; Marcela Ferres [Chili] ; Randy A. Albrecht [États-Unis] ; Adolfo García-Sastre [États-Unis] ; Nicole M. Bouvier [États-Unis] ; Kimihito Ito [Japon] ; Rafael A. Medina [États-Unis, Chili] ; Peter Palese [États-Unis] ; Florian Krammer [États-Unis]Source :
- Nature immunology [ 1529-2908 ] ; 2017.
Abstract
Influenza virus infections induce antibodies against the viral surface glycoproteins hemagglutinin and neuraminidase, and these responses can be broadly protective. To test the breadth and magnitude of antibody responses, mice, guinea pigs and ferrets were sequentially infected with divergent H1N1 or H3N2 viruses. Antibody responses were measured by ELISA against an extensive panel of recombinant glycoproteins representing the viral diversity in nature. Guinea pigs developed high titers of broadly cross-reactive antibodies; mice and ferrets exhibited narrower humoral responses. Then, we compared antibody responses after H1N1 or H3N2 infections in humans and found markedly broad responses and cogent evidence for original antigenic sin. This work will inform universal influenza vaccine design and can guide pandemic preparedness efforts against emerging influenza viruses.
Url:
DOI: 10.1038/ni.3684
PubMed: 28192418
PubMed Central: 5360498
Affiliations:
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xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hirsh, Ariana" sort="Hirsh, Ariana" uniqKey="Hirsh A" first="Ariana" last="Hirsh">Ariana Hirsh</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Margine, Irina" sort="Margine, Irina" uniqKey="Margine I" first="Irina" last="Margine">Irina Margine</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Iida, Sayaka" sort="Iida, Sayaka" uniqKey="Iida S" first="Sayaka" last="Iida">Sayaka Iida</name><affiliation wicri:level="1"><nlm:aff id="A3">Division of Bioinformatics, Hokkaido University Research Center for Zoonosis Control, Kitaku, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Bioinformatics, Hokkaido University Research Center for Zoonosis Control, Kitaku</wicri:regionArea><wicri:noRegion>Kitaku</wicri:noRegion></affiliation></author><author><name sortKey="Barrera, Aldo" sort="Barrera, Aldo" uniqKey="Barrera A" first="Aldo" last="Barrera">Aldo Barrera</name><affiliation wicri:level="1"><nlm:aff id="A4">Departamento de Infectología e Inmunología Pediátrica, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Infectología e Inmunología Pediátrica, School of Medicine, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Ferres, Marcela" sort="Ferres, Marcela" uniqKey="Ferres M" first="Marcela" last="Ferres">Marcela Ferres</name><affiliation wicri:level="1"><nlm:aff id="A4">Departamento de Infectología e Inmunología Pediátrica, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Infectología e Inmunología Pediátrica, School of Medicine, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Albrecht, Randy A" sort="Albrecht, Randy A" uniqKey="Albrecht R" first="Randy A." last="Albrecht">Randy A. 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Bouvier</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ito, Kimihito" sort="Ito, Kimihito" uniqKey="Ito K" first="Kimihito" last="Ito">Kimihito Ito</name><affiliation wicri:level="1"><nlm:aff id="A3">Division of Bioinformatics, Hokkaido University Research Center for Zoonosis Control, Kitaku, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Bioinformatics, Hokkaido University Research Center for Zoonosis Control, Kitaku</wicri:regionArea><wicri:noRegion>Kitaku</wicri:noRegion></affiliation></author><author><name sortKey="Medina, Rafael A" sort="Medina, Rafael A" uniqKey="Medina R" first="Rafael A." last="Medina">Rafael A. Medina</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Departamento de Infectología e Inmunología Pediátrica, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Infectología e Inmunología Pediátrica, School of Medicine, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile</nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Palese, Peter" sort="Palese, Peter" uniqKey="Palese P" first="Peter" last="Palese">Peter Palese</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Nature immunology</title><idno type="ISSN">1529-2908</idno><idno type="eISSN">1529-2916</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p id="P2">Influenza virus infections induce antibodies against the viral surface glycoproteins hemagglutinin and neuraminidase, and these responses can be broadly protective. To test the breadth and magnitude of antibody responses, mice, guinea pigs and ferrets were sequentially infected with divergent H1N1 or H3N2 viruses. Antibody responses were measured by ELISA against an extensive panel of recombinant glycoproteins representing the viral diversity in nature. Guinea pigs developed high titers of broadly cross-reactive antibodies; mice and ferrets exhibited narrower humoral responses. Then, we compared antibody responses after H1N1 or H3N2 infections in humans and found markedly broad responses and cogent evidence for original antigenic sin. This work will inform universal influenza vaccine design and can guide pandemic preparedness efforts against emerging influenza viruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jayasundara, K" uniqKey="Jayasundara K">K Jayasundara</name></author><author><name sortKey="Soobiah, C" uniqKey="Soobiah C">C Soobiah</name></author><author><name sortKey="Thommes, E" uniqKey="Thommes E">E Thommes</name></author><author><name sortKey="Tricco, Ac" uniqKey="Tricco A">AC Tricco</name></author><author><name sortKey="Chit, A" uniqKey="Chit A">A Chit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horimoto, T" uniqKey="Horimoto T">T Horimoto</name></author><author><name sortKey="Kawaoka, Y" 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Albrecht</name><name sortKey="Albrecht, Randy A" sort="Albrecht, Randy A" uniqKey="Albrecht R" first="Randy A." last="Albrecht">Randy A. Albrecht</name><name sortKey="Bouvier, Nicole M" sort="Bouvier, Nicole M" uniqKey="Bouvier N" first="Nicole M." last="Bouvier">Nicole M. Bouvier</name><name sortKey="Bouvier, Nicole M" sort="Bouvier, Nicole M" uniqKey="Bouvier N" first="Nicole M." last="Bouvier">Nicole M. Bouvier</name><name sortKey="Choi, Angela" sort="Choi, Angela" uniqKey="Choi A" first="Angela" last="Choi">Angela Choi</name><name sortKey="Choi, Angela" sort="Choi, Angela" uniqKey="Choi A" first="Angela" last="Choi">Angela Choi</name><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><name sortKey="Hirsh, Ariana" sort="Hirsh, Ariana" uniqKey="Hirsh A" first="Ariana" last="Hirsh">Ariana Hirsh</name><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name><name sortKey="Margine, Irina" sort="Margine, Irina" uniqKey="Margine I" first="Irina" last="Margine">Irina Margine</name><name sortKey="Medina, Rafael A" sort="Medina, Rafael A" uniqKey="Medina R" first="Rafael A." last="Medina">Rafael A. Medina</name><name sortKey="Palese, Peter" sort="Palese, Peter" uniqKey="Palese P" first="Peter" last="Palese">Peter Palese</name><name sortKey="Palese, Peter" sort="Palese, Peter" uniqKey="Palese P" first="Peter" last="Palese">Peter Palese</name></country><country name="Japon"><noRegion><name sortKey="Iida, Sayaka" sort="Iida, Sayaka" uniqKey="Iida S" first="Sayaka" last="Iida">Sayaka Iida</name></noRegion><name sortKey="Ito, Kimihito" sort="Ito, Kimihito" uniqKey="Ito K" first="Kimihito" last="Ito">Kimihito Ito</name></country><country name="Chili"><noRegion><name sortKey="Barrera, Aldo" sort="Barrera, Aldo" uniqKey="Barrera A" first="Aldo" last="Barrera">Aldo Barrera</name></noRegion><name sortKey="Ferres, Marcela" sort="Ferres, Marcela" uniqKey="Ferres M" first="Marcela" last="Ferres">Marcela Ferres</name><name sortKey="Medina, Rafael A" sort="Medina, Rafael A" uniqKey="Medina R" first="Rafael A." last="Medina">Rafael A. Medina</name><name sortKey="Medina, Rafael A" sort="Medina, Rafael A" uniqKey="Medina R" first="Rafael A." last="Medina">Rafael A. Medina</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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